How to read this
Research Hub
How to read this
Three minutes on how evidence works in supplements, before any of the research itself. It applies to every product on the shelf, ours included.
We publish the research behind everything we sell — what has been studied, how strong it is, and where it is thinner than we would like. That is only useful if you can tell a strong study from a weak one. Most of what appears on supplement packaging is designed to blur exactly that line.
1 · Evidence attaches to specifics
A label might say inositol, or magnesium, or a plant name. Each of those is a category, not the thing that was tested.
Dose matters. A trial run at 4,000mg says nothing about 500mg of the same substance. So does form: magnesium glycinate and magnesium oxide are absorbed differently, and a study of one is not a study of the other.
What to look for: a dose and a form. Where a product claims research without giving both, no published trial can be attached to what is in the bottle.
2 · A patent is not a clinical trial
These two get used interchangeably in supplement marketing, and they are not remotely the same thing.
A clinical trial tests whether something works in people, usually against a placebo, and is published somewhere others can check it.
A patent is a legal claim that an invention is new and useful. It is granted by a patent office rather than a journal. It does not require the invention to have been tested in a single human being, and it is not peer reviewed.
Both are real documents, and both are checkable. But "patented ingredient" is not saying what most people hear when they read it.
3 · Two phrases that mean the opposite of what they sound like
"Insufficient evidence" means there are not enough good trials to judge. It does not mean something was tested and shown not to work. Those two readings get treated as the same and they are not.
"Low quality evidence" is not a verdict on how carefully a trial was run. It is a rating applied to a whole body of research, and it is marked down when the studies are small, short, inconsistent with one another, or funded by someone with an interest in the outcome. A field can lean consistently towards a benefit and still be rated low quality, because the two judgements — which way it points, and how much confidence to place in it — are made separately.
4 · Research follows commercial exclusivity, not biology
The part almost nobody explains, and the one that makes sense of the rest.
A decent clinical trial costs six figures. A company will fund one only where it can own the result — which means owning the thing being tested. So an ingredient house registers a specification, trademarks its name, funds the trial, and the name becomes the asset. Anyone can buy a generic extract. Only one company can sell its own branded one.
Two things follow from that, and they pull in opposite directions.
An ingredient with no published research has not necessarily failed. More often nobody could own the answer, so nobody paid to find out.
And an ingredient that does have published trials is genuinely better documented. Paying more for it is rational. When a brand uses an ingredient with decades of published human research behind it, that research is real, it cost real money, and it is worth something.
The honest summary: absence of evidence is not evidence of absence — and it is not evidence of presence either. It is a gap, and it should be labelled as one rather than filled with adjectives.
How we grade what we sell
Published next to every ingredient, whatever it says.
- AMultiple human randomised trials on this exact ingredient, at this dose and form
- BOne human randomised trial on this exact ingredient, dose and form
- CHuman trials exist on the substance or species, but not on the specific version we use
- DPatent, laboratory or animal evidence only
- ENo evidence located
Nutrients carrying a health claim authorised in law sit outside this scale. For those, the wording is fixed by regulation and we state it exactly as written, with nothing added.
Some of our ingredients grade well. Some grade poorly. We publish both. A low grade does not mean an ingredient is useless — it means we cannot show you a study, and we would rather say so than reach for a phrase like "clinically studied" that does not survive being checked.
Where we could not read a study in full, we say that too, and list it as unread. It costs nothing, and it is the clearest signal we can give that the list is not curated.
What these pages are not
Nothing here is a claim that our products treat, prevent or cure anything. UK law is strict about what a food supplement may say, and rightly so.
Where a claim is authorised in law we state it in the exact words the regulation permits, attached to the specific nutrient that carries it. Everywhere else we describe what is in the product and how the research behind it was done.
In Belle Balance, four nutrients carry authorised claims: magnesium, vitamin C, vitamin B6 and chromium. Inositol is not one of them. We cannot tell you what our inositol does. We can tell you exactly how much of it is in there, and how that compares with the amount the research uses.