Xylo-oligosaccharides

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Xylo-oligosaccharides

The fibre that sits beside the live cultures in every capsule. At 250mg it is a companion to the cultures rather than a standalone dose — and this page sets out exactly what that means.

In short

Femme Flora contains 250mg of xylo-oligosaccharides, a fibre made from corncob by an authorised process and included alongside the live cultures. Standalone XOS trials used around 1.4g a day, so we make no claim for it on its own. This page sets out why it is in the formula and why the amount is what it is.

How we grade

  • AMultiple human randomised trials on this exact ingredient, at this dose and form
  • BOne human randomised trial on this exact ingredient, dose and form
  • CHuman trials exist on the substance, but not on the version we use
  • DPatent, laboratory or animal evidence only
  • ENo evidence located

XOS grades C. Good human trials exist on xylo-oligosaccharides, and when it was tested on its own they used roughly 1.4 grams a day or more. We carry 250 milligrams, so we make no claim for it as a standalone ingredient. It is in Femme Flora as a companion to the live cultures, and section 4 sets out what that does and does not allow us to say.

Why we use it

XOS is in Femme Flora as the fibre paired with its live cultures. We chose it over other fibres for three reasons: it has been studied at lower intakes than FOS, it is generally better tolerated, and it is plant-derived.

Those reasons are about choosing the right fibre, not a claim about what 250mg does on its own. The rest of this page is about the amount, and why it is what it is.

1 · What xylo-oligosaccharides are

Xylo-oligosaccharides — XOS — are short chains of xylose sugar units, made by breaking down the fibre in plant material with an enzyme. Ours is derived from corncob. They are classed as a fibre that the human gut cannot digest, which instead reaches the large intestine intact.

They are a regulated novel food in Great Britain, authorised under a specific production route — corncob substrate, hydrolysed with a xylanase enzyme, then purified. The authorisation sets a maximum of 2g a day in food supplements, and requires the label to read “Xylo-Oligosaccharides” in that exact form. Our 250mg is comfortably inside the limit.

Both parts are confirmed. Our manufacturer has confirmed in writing the corncob substrate and the production route: hydrolysis with a xylanase enzyme from non-GM Trichoderma reesei, then purification, giving more than 95% XOS. That is the route the authorisation covers.

2 · The dose, stated plainly

Daily intakes at which prebiotic effects have been demonstrated in humans, against ours.
Prebiotic Lowest effective daily intake
FOS ~2.5 g
GOS 0.5–1.3 g
XOS ~1.4 g
Femme Flora 0.25 g

XOS is the best of those three for a capsule, because its threshold is the one closest to reachable. Even so, 250mg is roughly 18% of the lowest intake at which it has been shown to work on its own, which is why we make no standalone claim for it.

3 · Why we cannot simply put more in

The honest answer is that a capsule is a small place. A daily serving of Femme Flora is two size 0 capsules, and they already hold 50 billion live cultures, 150mg of cranberry extract, four vitamins and the XOS. Reaching 1.4 grams of XOS would need roughly two to three additional capsules for the fibre alone.

That is a real constraint, and it is why the amount is set by what the capsule can hold alongside the cultures rather than by the standalone trials. Section 4 explains the reasoning for including it anyway, and where its limits are.

4 · The case for including it, and its limits

The reasoning behind a fibre included alongside cultures, and what it does not let us say.

In 2019 the International Scientific Association for Probiotics and Prebiotics set out a definition of a synergistic synbiotic: a combination in which the prebiotic is chosen specifically to be used by the live cultures it is packaged with, rather than to work on its own.

Under that definition the components do not individually have to meet their standalone thresholds. A sub-threshold prebiotic can be legitimate if it is feeding the organisms in the same capsule. On its face that describes exactly what we have built.

But the definition carries a condition, and the condition is the whole point of it. A synergistic synbiotic has to be tested as a finished product and shown to produce a health benefit. It is not a label you may apply because the components look complementary. It is a claim about a specific combination, demonstrated on that combination.

Femme Flora has not been tested as a finished product. So we include XOS as the fibre that sits beside the cultures, on the reasoning above, and we do not call the product a synbiotic.

5 · The decision we made

We kept it, at 250mg. Before manufacture we weighed three options: remove it, keep it at the amount the capsule allows, or test the finished product first. We kept it, because it is the fibre the cultures are paired with in the formula, and because the alternative was dropping it for an amount the capsule could never hold.

What that means in practice: we list it as an ingredient, at its exact amount, and we make no claim for it on its own. As with Belle Balance, each batch’s certificate of analysis will be published on our verify page.

6 · What we can tell you about our XOS specifically

  • Source: plant-derived, extracted from corncob. Confirmed by our manufacturer.
  • Vegan: yes. Confirmed by our manufacturer. Unlike GOS, which is produced from lactose and is therefore usually not vegan — one of the reasons we chose XOS.
  • FOS content: none. We asked for FOS to be removed and our manufacturer confirmed that none is blended into the raw material.
  • Novel food status: XOS is an authorised novel food in Great Britain. That authorisation is specific — it covers XOS produced from corncob using a particular enzyme. The corncob source is confirmed. Our manufacturer has also confirmed the enzyme route in writing: xylanase from non-GM Trichoderma reesei, purified to more than 95% XOS.
  • Label name: the authorisation also fixes how it must be written on the pack. It appears as Xylo-Oligosaccharides, in that exact form.

What we do not claim

  • XOS has no authorised health claim in Great Britain. We make none.
  • We do not use the word "prebiotic" as a benefit. In UK law it functions as a health claim in its own right, and separately we could not support it at this dose even if it did not.
  • We do not claim our 250mg feeds your gut bacteria, supports your microbiome, or does anything else. It is below the intake at which such effects have been demonstrated.
  • We do not call this product a synbiotic, synergistic or otherwise, because we have not done the testing that word requires.
  • We do not claim this product treats, prevents or reduces the risk of anything.

What we claim is the composition: 250mg of xylo-oligosaccharides from corncob per daily serving — listed at its exact amount, with no standalone claim.

Common questions

How much XOS is in Femme Flora?
250mg per daily serving. The intakes used in published research are closer to 1.4g a day, so ours sits well below them. We state this openly rather than listing the ingredient and letting its presence imply a researched dose.
What are xylo-oligosaccharides?
Short chains of xylose sugar units, produced by breaking down plant fibre with an enzyme. Ours is derived from corncob. They are a fibre, meaning the human gut cannot digest them and they reach the large intestine intact.
Is XOS a novel food in the UK?
Yes. It is authorised in Great Britain under a specific production route: corncob substrate, hydrolysed with a xylanase enzyme, then purified. The authorisation caps food supplement use at 2g a day and requires the exact label wording "Xylo-Oligosaccharides".
Does XOS have an approved health claim in the UK?
No. There is no authorised health claim for xylo-oligosaccharides, or for prebiotic fibres as a category, on the GB Nutrition and Health Claims Register. We make no claim for it anywhere on our packaging or our site.
Why include XOS at a dose below the research?
As the fibre that sits beside the live cultures. Two capsules cannot hold the 1.4g used in standalone trials alongside 50 billion cultures, cranberry and four vitamins, so we include the amount the capsule allows and make no claim for it on its own.

Sources

  1. GB Nutrition and Health Claims Register. Checked against the register export of 19 May 2026. No authorised health claim for xylo-oligosaccharides, or for any prebiotic.
  2. Commission Implementing Regulation (EU) 2018/1648, as retained in Great Britain. GB Novel Foods authorisation, xylo-oligosaccharides. Authorisation is specific to the source material and production process. Our manufacturer has confirmed the corncob source and the xylanase route in writing (October 2026).
  3. Swanson K.S. et al. (2020) The ISAPP consensus statement on the definition and scope of synbiotics. Nature Reviews Gastroenterology & Hepatology 17:687–701. Source of the synergistic-synbiotic definition and of the finished-product testing requirement.
  4. Comparative prebiotic dose literature. FOS bifidogenic threshold ~2.5g/day; GOS demonstrated from 0.5g; XOS from ~1.4g, with lower FODMAP load and better tolerability than FOS.
  5. Manufacturer correspondence, Shaanxi Xinyide, 6 August 2026. Confirms corncob source, vegan suitability and absence of FOS. The enzyme route was confirmed separately in October 2026.
Last reviewed 2 November 2026. Reviewed quarterly, and whenever a finding changes a grade — including downwards.